Measure Twice, Close Once

Re: Measure once or twice--does it really matter?

The editorial (1) on our article (2) makes a number of points, and we wish to address these with some further explanation. The first clarification concerns our theoretical section. Our argument is, in fact, more pragmatic rather than mathematical and is indeed the point that the editorial identifies as " largely due to difference in scales. " From its definition as an x% reduction, any measure ...

Once bitten, twice shy.

Once-Weekly Exenatide Versus Once- or Twice-Daily Insulin Detemir

OBJECTIVE This multicenter, open-label, parallel-arm study compared the efficacy and safety of exenatide once weekly (EQW) with titrated insulin detemir in patients with type 2 diabetes inadequately controlled with metformin (with or without sulfonylureas). RESEARCH DESIGN AND METHODS Patients were randomized to EQW (2 mg) or detemir (once or twice daily, titrated to achieve fasting plasma gl...

Once– versus twice–daily tacrolimus: are the formulations equivalent?

Tacrolimus is one of the most often used immuno-suppressive drugs in organ transplantation. It was first approved in 1994 for use in liver transplanta-tion, replacing cyclosporine A, due to better absorption properties regardless of bile secretion. Then it use was extended to other organs and nowadays more that 90% of kidney graft recipient in the United States receive tacrolimus as a basic imm...

Short-term memory for pictures seen once or twice

The present study is concerned with the effects of exposure time, repetition, spacing and lag on old/new recognition memory for generic visual scenes presented in a RSVP paradigm. Early memory studies with verbal material found that knowledge of total exposure time at study is sufficient to accurately predict memory performance at test (the Total Time Hypothesis), irrespective of number of repe...